Preparation of Tertiary Amine Oxides by Ozonization

It is reported in the early literature that unsymmetrical amine oxides or those of high molecular weight cannot be prepared by the action of ozone on the amine. This study shows that an unsymmetrical amine oxide, such as N -ethylpiperidine oxide, and a symmetrical high molecular weight amine oxide, such as tri- n -hexylamine oxide, can be prepared by ozonization in methanol solution.