Formation of N‐Hydroxy‐amines of Spin Labeled Nucleosides for 1H‐NMR. Analysis

Abstract Amine‐oxide radical 1a was efficiently converted to the corresponding N ‐hydroxy‐amine 2a with sodium dithionite in acetone/water. This reaction was used to develop a procedure for monitoring the NMR. spectra of sodium dithionite reduced amine‐oxide radicals and of novel reduced amine‐oxide‐labeled nucleosides.