神经科学
被盖腹侧区
多巴胺
黑质
中脑
致密部
纹状体
多巴胺能
体感系统
生物
心理学
中枢神经系统
作者
Mitsuko Watabe-Uchida,Lihua Zhu,Shuji Ogawa,Archana Vamanrao,Naoshige Uchida
出处
期刊:Neuron
[Elsevier]
日期:2012-06-01
卷期号:74 (5): 858-873
被引量:1046
标识
DOI:10.1016/j.neuron.2012.03.017
摘要
Recent studies indicate that dopamine neurons in the ventral tegmental area (VTA) and substantia nigra pars compacta (SNc) convey distinct signals. To explore this difference, we comprehensively identified each area's monosynaptic inputs using the rabies virus. We show that dopamine neurons in both areas integrate inputs from a more diverse collection of areas than previously thought, including autonomic, motor, and somatosensory areas. SNc and VTA dopamine neurons receive contrasting excitatory inputs: the former from the somatosensory/motor cortex and subthalamic nucleus, which may explain their short-latency responses to salient events; and the latter from the lateral hypothalamus, which may explain their involvement in value coding. We demonstrate that neurons in the striatum that project directly to dopamine neurons form patches in both the dorsal and ventral striatum, whereas those projecting to GABAergic neurons are distributed in the matrix compartment. Neuron-type-specific connectivity lays a foundation for studying how dopamine neurons compute outputs.
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