生物
遗传学
限制性片段长度多态性
基因定位
基因座(遗传学)
删除映射
种内竞争
等位基因
多基因
遗传连锁
回交
基因型
遗传标记
染色体
基因
分子生物学
数量性状位点
生态学
作者
Jeffrey M. Friedman,Rudolph L. Leibel,D.S. Siegel,J. Walsh,Nathan Bahary
出处
期刊:Genomics
[Elsevier]
日期:1991-12-01
卷期号:11 (4): 1054-1062
被引量:158
标识
DOI:10.1016/0888-7543(91)90032-a
摘要
The mouse ob mutation has been mapped relative to a series of RFLPs among the progeny of three separate mouse crosses: an intraspecific backcross, an intraspecific intercross, and an interspecific intercross. Genotypic assignment at the ob locus was made by making use of measurements of body mass index and the plasma concentrations of glucose and insulin. These data have suggested that the development of diabetes in these animals is a consequence of unlinked polygenes. There was also evidence that unlinked Mus spretus alleles can diminish the obesity of ob/ob mice. From these data we have mapped several markers on chromosome 6 with the following order: cen-Cola-2-Met-ob-Cpa-Tcrb. The homologs of markers that flank ob map to human chromosome 7q, suggesting that if there is a human homologue of ob, it maps to 7q31.
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