1417 CORRELATION BETWEEN EXPRESSION OF α1-ADRENOCEPTOR SUBTYPE MRNA AND SEVERITY OF LOWER URINARY TRACT SYMPTOMS OR BLADDER OUTLET OBSTRUCTION IN BENIGN PROSTATIC HYPERPLASIA PATIENTS

You have accessJournal of UrologyBenign Prostatic Hyperplasia: Basic Research1 Apr 20101417 CORRELATION BETWEEN EXPRESSION OF α1-ADRENOCEPTOR SUBTYPE MRNA AND SEVERITY OF LOWER URINARY TRACT SYMPTOMS OR BLADDER OUTLET OBSTRUCTION IN BENIGN PROSTATIC HYPERPLASIA PATIENTS Yoshiyuki Kojima, Shoichi Sasaki, Yasue Kubota, Yuraro Hayashi, and Kenjiro Kohri Yoshiyuki KojimaYoshiyuki Kojima More articles by this author , Shoichi SasakiShoichi Sasaki More articles by this author , Yasue KubotaYasue Kubota More articles by this author , Yuraro HayashiYuraro Hayashi More articles by this author , and Kenjiro KohriKenjiro Kohri More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.02.1109AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Lower urinary tract symptoms (LUTS) and bladder outlet obstruction (BOO) can be linked to an α1-AR-dependent increase in smooth muscle tone, predominantly in the capsule of the prostate and bladder neck. However, whether α1-AR stimulation is associated with LUTS and BOO directly or how impaired α1-AR stimulation results in LUTS and BOO lacks a convincing explanation. We examined whether a direct correlation between the expression of α1-AR subtype mRNA in the prostate and clinical findings exists in BPH patients, and discuss the pathophysiology of BPH. METHODS Sixty-eight patients (68.9+/-7.0) with LUTS and BOO secondary to BPH were enrolled in this study. Four prostate needle biopsy specimens were obtained from the transition zone and Taqman quantitative RT-PCR was performed to examine the expression level of α-AR subtypes. Peason′s correlation coefficient and multiple regression analyses were used assess the correlations between the α1a-, α1b-, α1d- or total α1-AR subtype mRNA expression level and all individual symptoms of IPSS, or total IPSS. Stepwise multiple regression analysis was also performed to examine the correlations between these expression levels and patient age, prostate volume, IPSS, QOL idex, max flow rate in uroflowmetry (Qmax) and post-void residual urine volume (PVR). RESULTS Pearson′s correlation coefficient and multiple regression analyses demonstrated no correlations between each α1-AR subtype mRNA expression level and all individual symptoms of IPSS, or total IPSS. Stepwise multiple regression analysis demonstrated that the expression levels of α1a-AR, α1d-AR and total α1-AR mRNA had a significant positive correlation with patient age, but no correlation of expression levels of each α1-AR subtype mRNA with prostate volume, IPSS, QOL index, Qmax and PVR was insignificant. CONCLUSIONS The increase of expression levels α1a-AR, α1d-AR and total α1-AR mRNA with age may lead to increased prostatic urethral pressure and LUTS in elderly men, and may be an important factor in the pathogenesis of clinically significant BPH. However, no direct correlation was found between the expression of α1-AR subtype mRNA in the prostate and severity of LUTS or BOO in BPH patients, suggesting that LUTS and BOO may be associated multiple factors and several other conditions may include the cause of LUTS and BOO. Nagoya, Japan© 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 183Issue 4SApril 2010Page: e546 Peer Review Report Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.MetricsAuthor Information Yoshiyuki Kojima More articles by this author Shoichi Sasaki More articles by this author Yasue Kubota More articles by this author Yuraro Hayashi More articles by this author Kenjiro Kohri More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...