深共晶溶剂
氯化胆碱
甲酰胺类
共晶体系
化学
溶剂
催化作用
原甲酸三乙酯
甲酸
甲酰化
有机化学
甲酰胺
合金
作者
Najmedin Azizi,Elham Gholibeglo,Mahbobe Babapour,Hossein Ghafuri,Seyed Mohammad Bolourtchian
标识
DOI:10.1016/j.crci.2012.06.011
摘要
A deep eutectic solvent was used as a dual catalyst and reaction medium for the efficient N-formylation of aromatic amines without hazardous organic solvent and catalyst. Treatment of aromatic amines with trimethyl orthoformate and formic acid in deep eutectic solvent at 70 °C gives the corresponding N-formyl derivatives in good to excellent yields. This simple ammonium deep eutectic solvent, easily synthesized from choline chloride and SnCl2, with 100% atom economy and making it applicable to industry and laboratory. Furthermore, heating the trimethyl orthoformate and aromatic primary amines in the deep eutectic solvent results in formation of the corresponding N,N’-diarylamidines in high yields.
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