胰岛素样生长因子1受体
SOCS2
生长激素受体
受体
细胞生物学
雌激素相关受体γ
生长激素释放激素受体
酶联受体
原癌基因酪氨酸蛋白激酶Src
细胞因子受体
激素受体
癌症研究
生长因子受体
促甲状腺激素释放激素受体
化学
生物
激素
核受体
信号转导
生物化学
生长因子
生长激素
转录因子
遗传学
癌症
基因
抑制器
乳腺癌
作者
Andrew J. Brooks,Jong Wei Wooh,Kathryn A. Tunny,Michael J. Waters
标识
DOI:10.1016/j.biocel.2007.07.008
摘要
The growth hormone receptor has been an archetype for ligand-induced receptor dimerisation in cytokine receptor signalling. However, we now know that it exists as a constitutive dimer and is activated by a reorganisation of receptor subunits as a result of asymmetric placement of two receptor binding sites on the hormone monomer. This review highlights several topics including: current models of receptor activation; recent advances in the understanding of GH signalling demonstrating that ligand-induced signalling activates Src/ERK pathway in parallel to the classical JAK2-STAT5 signalling; and the nuclear localised growth hormone receptor correlates with high proliferation status and carcinogenesis.
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