细胞生物学
转化生长因子
功能(生物学)
先天免疫系统
受体
作者
Mark A. Travis,Dean Sheppard
出处
期刊:Annual Review of Immunology
[Annual Reviews]
日期:2014-03-21
卷期号:32 (1): 51-82
被引量:441
标识
DOI:10.1146/annurev-immunol-032713-120257
摘要
The cytokine TGF-β plays an integral role in regulating immune responses. TGF-β has pleiotropic effects on adaptive immunity, especially in the regulation of effector and regulatory CD4(+) T cell responses. Many immune and nonimmune cells can produce TGF-β, but it is always produced as an inactive complex that must be activated to exert functional effects. Thus, activation of latent TGF-β provides a crucial layer of regulation that controls TGF-β function. In this review, we highlight some of the important functional roles for TGF-β in immunity, focusing on its context-specific roles in either dampening or promoting T cell responses. We also describe how activation of TGF-β controls its function in the immune system, with a focus on the key roles for members of the integrin family in this process.
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