合成生物学
酵母
计算生物学
酿酒酵母
模式生物
系统生物学
代谢工程
有机体
生物
生化工程
生物技术
基因
遗传学
工程类
作者
Zihe Liu,Yueping Zhang,Jens Nielsen
出处
期刊:Biochemistry
[American Chemical Society]
日期:2019-01-08
卷期号:58 (11): 1511-1520
被引量:28
标识
DOI:10.1021/acs.biochem.8b01236
摘要
With the rapid development of DNA synthesis and next-generation sequencing, synthetic biology that aims to standardize, modularize, and innovate cellular functions, has achieved vast progress. Here we review key advances in synthetic biology of the yeast Saccharomyces cerevisiae, which serves as an important eukaryal model organism and widely applied cell factory. This covers the development of new building blocks, i.e., promoters, terminators and enzymes, pathway engineering, tools developments, and gene circuits utilization. We will also summarize impacts of synthetic biology on both basic and applied biology, and end with further directions for advancing synthetic biology in yeast.
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