Effect of Granulocyte (-Macrophage) Colony-Stimulating Factor on Oral Mucositis Due to Concomitant Chemoradiotherapy in Locally Advanced Head and Neck Cancer Patients

Objective: To evaluate the efficacy of granulocyte(-macrophage) colony stimulating factor[G(M)-CSF] in the treatment of concomitant chemoradiotherapy-induced oral mucositis in locally advanced head and neck cancer patients. Metheds: Fifteen patients with locally advanced head and neck cancer was received concomitant chemoradiotherapy, while white blood cell count were less than 1. 5×10~9/L with grade Ⅲ/Ⅳ oral mucositis, they were subcutaneously given G(M)- CSF at dose of 100-300μg daily for 3～10 days. Results: After administration of G(M)-CSF, all of the patients had an augmantation of white blood cell count more than 5. 0×10~9/L. Complete healing of oral mucositis occurred in 1 patient (CR), partial in 8 patients(PR), whereas 6 patients had no change and none was progressive, the objective response rate (CR+PR) was 60%. Condusions: G(M)-CSF is proved effective for oral mucositis caused by concomitant chemoradio- therapy in locally advanced head and neck cancer patients.