Objective To report 89 cases of total knee arthroplasty,the curative effect of treating osteoarthrosis and rheumatoid arthritis. Methods 89 cases of patients with total knee arthroplasty were followed up,and the HSS score system was analyzed; they were followed up for 6- 36 months,an average of 21 months. Record a deep vein thrombosis early after surgery and complications of infection,the reasons of complications were analyzed. Results The follow up showed that excellent and good results were achieved in 87. 6 %. Patients in the postoperative pain,function had been improved significantly,especially in terms of pain relief effect is remarkable. But early postoperative deep vein thrombosis of the fatality rate was extremely high,infection leading to operation failure rate was higher. Conclusion Total knee replacement presented a satisfactory procedure to serious osteoarthritis of the knee,but with more perioperative complications,prevention of deep vein thrombosis and infection was an important means to improve the success rate of surgery.