细胞内
超氧化物歧化酶
化学
抗氧化剂
活性氧
过氧化氢酶
谷胱甘肽过氧化物酶
氧化应激
生物物理学
纳米材料
体内
生物化学
细胞生物学
纳米技术
材料科学
生物
生物技术
作者
Yanyan Huang,Zhen Liu,Chaoqun Liu,Enguo Ju,Yan Zhang,Jinsong Ren,Xiaogang Qu
标识
DOI:10.1002/anie.201600868
摘要
In this work, for the first time, we constructed a novel multi-nanozymes cooperative platform to mimic intracellular antioxidant enzyme-based defense system. V2 O5 nanowire served as a glutathione peroxidase (GPx) mimic while MnO2 nanoparticle was used to mimic superoxide dismutase (SOD) and catalase (CAT). Dopamine was used as a linker to achieve the assembling of the nanomaterials. The obtained V2 O5 @pDA@MnO2 nanocomposite could serve as one multi-nanozyme model to mimic intracellular antioxidant enzyme-based defense procedure in which, for example SOD, CAT, and GPx co-participate. In addition, through assembling with dopamine, the hybrid nanocomposites provided synergistic antioxidative effect. Importantly, both in vitro and in vivo experiments demonstrated that our biocompatible system exhibited excellent intracellular reactive oxygen species (ROS) removal ability to protect cell components against oxidative stress, showing its potential application in inflammation therapy.
科研通智能强力驱动
Strongly Powered by AbleSci AI