MCF-7型
癌症研究
胰腺癌
肿瘤科
结直肠癌
癌症
癌细胞系
乳腺癌
癌细胞
内科学
医学
人体乳房
作者
Jennifer Noro,João Maciel
出处
期刊:Organic chemistry
[OMICS Publishing Group]
日期:2015-01-01
卷期号:04 (03)
被引量:5
标识
DOI:10.4172/2161-0401.1000144
摘要
New 1,8-naphthalimido derivatives with 2,3 and 4 carbon chains bearing a number of different functionalities were synthesized and tested against a panel of breast cancer MCF-7, colon cancer HCT-15 and pancreatic cancer BxPC-3 cell lines.Generally structures with shorter alkyl chains were more active, with the one exception of the amide containing a p-nitrophenyl group.GI50 values (µM) were determined for the most active compounds.Three compounds exhibited GI50 values below 5 µM, two with MCF-7 cells, and one other with HCT-15.Compounds with different functionalities demonstrated cell line specificity: the MCF-7 cell line was more sensitive to an urea derivative (6f), the growth of HCT-15 cells were most affected by a triazole (9d), while the BxPC-3 cell line was inhibited in a higher extend by a guanidine (4a).
科研通智能强力驱动
Strongly Powered by AbleSci AI