Two New Limonoids from the Fruits of Melia azedarach (Meliaceae)

Abstract Two new limonoids, trichilinin M ( 1 ) and ohchinin benzoate ( 2 ), along with two known limonoids, 12‐hydroxyamoorastatone ( 3 ) and mesendanin H ( 4 ), were isolated from the fruits of Melia azedarach Linn. The structures of new limonoids were determined by analyses of HR‐ESI‐MS, 1D and 2D NMR (HSQC, HMBC and NOESY) data. All compounds were evaluated against human pancreatic cancer PANC1 cells and the results showed that compounds 3 – 4 exhibited substantial cytotoxic activity ( 3 : IC 50 =4.55 μM; 4 : IC 50 =7.54 μM), and compounds 1 – 2 exhibited moderate cytotoxicity ( 1 : IC 50 =27.06 μM; 2 : IC 50 =21.17 μM).