3D/4D Reconstruction and Quantitative Total Body Imaging

Total-body PET image reconstruction follows a similar procedure to the image reconstruction process for standard whole-body PET scanners. One unique aspect of total-body imaging is simultaneous coverage of the entire human body, which makes it convenient to perform total-body dynamic PET scans. Therefore, four-dimensional dynamic PET reconstruction and parametric imaging are of great interest in total-body imaging. This article covers some basics of PET image reconstruction and then focuses on three- and four-dimensional PET reconstruction for total-body imaging. Methods for image formation from raw measurements in total-body PET are described. Challenges and opportunities in total-body PET image reconstruction are discussed.