血清素转运体
溃疡性结肠炎
血清素
回肠炎
再摄取
5-羟色胺质膜转运蛋白
结肠炎
肠上皮
内科学
胃肠病学
医学
克罗恩病
内分泌学
疾病
上皮
病理
受体
作者
Jonas Woll Jørandli,Silje Thorsvik,Helene Kolstad Skovdahl,Benedikt Kornfeld,Siri Sæterstad,Björn Gustafsson,Arne K. Sandvik,Atle van Beelen Granlund
出处
期刊:American Journal of Physiology-gastrointestinal and Liver Physiology
[American Physiological Society]
日期:2020-12-01
卷期号:319 (6): G761-G768
被引量:34
标识
DOI:10.1152/ajpgi.00244.2020
摘要
The serotonin reuptake transporter is potently reduced in inflamed areas of Crohn’s ileitis, Crohn’s colitis, and ulcerative colitis. The changes are localized to the intestinal epithelium and can be induced by TNF-α. The serotonin synthesis through tryptophan hydroxylase 1 is unchanged. This regulation is suggested as a mechanism underlying the increased extracellular serotonin levels associated with intestinal inflammation.
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