DOES MEAN PERFUSION PRESSURE DURING CARDIOPULMONARY BYPASS AFFECT RENAL FUNCTION?

BACKGROUND: \nAfter cardiac surgery acute kidney injury (AKI) is a common and \nserious condition carrying significant costs and is independently associated with increased \nmorbidity and mortality. During cardiopulmonary bypass (CPB) surgery, modifiable factors may \ncontri \nbute to post \n- \noperative AKI. Their prevention might be a potential target for \nnephroprotection and any other morbidity after cardiac surgery. \nMETHODS AND MATERIAL \n: \nThe objective of the present study was to identify and determine whether intraoperative \nhypot \nension or any other cofactor are independent risk factors for postoperative AKI defined by \nthe RIFLE (renal Risk, Injury, Failure, Loss of renal function and End \n- \nstage renal disease). \nOn \nbasis of this patients were divided into two groups according to rise \nin serum creatinine >0.3 \nmg/dl till 72 hrs postoperatively. Group B patients have developed AKI (n=34) and the remaining \npatients were in Group A. \nRESULT \n: \nIn our study we have found that mean arterial pressure \nduring CPB were less in group B patients compare to group A patients which was statistically \nsignificant (p<0.001). And in this group ICU stay and mortality rate were also high compare to \ngroup A pati \nent who had not developed AKI. \nCONCLUSION: \nLower MAP during CPB is \nassociated with development of postoperative renal derangement, leads to increase ICU stay and \nmortality. Larger studies are required to further support the evidence