[The relationship between lysosome-autophagy and the head and neck squamous cancer cell apoptosis].

Autophagy can be used as both a protective mechanism of cell survival and a mechanism of cell death.The dual mechanism has been the emphases and difficulties of our research.The latest research shows that autophagy plays an important role in occurrence,development, transfer and treatment of the cancer.Head and neck cancer is usually derived from the upper respiratory tract's. The upper digestive tract's malignant tumor, because of its complex anatomic structure, low 5 years of survival rate, to study the prevention and treatment has the extremely important significance. The purpose of this paper is to clarify the role of lysosome-autophagy,mitochondria-autophagy in the treatment of head and neck cancers and the relationship between autophagy and apoptosis, which will be contribute to the prevention and treatment of head and neck squamous cell carcinomas for us.Autophagy as a cellular lysosomal degradation pathway that can be used as a kind of dynamic monitoring index of the tumor.