肉桂
胰岛素抵抗
内分泌学
内科学
高胰岛素血症
胰岛素
生物
卡西亚
基础(医学)
线粒体
分泌物
医学
生物化学
病理
中医药
替代医学
作者
Eun Jung Ko,Min Young Um,Moonsung Choi,Taewon Han,Inho Kim,Sooim Shin
标识
DOI:10.1142/s0192415x20500317
摘要
Mitochondrial metabolism plays a crucial role in insulin resistance and insulin secretion in type 2 diabetes mellitus (T2D). Some studies have focused on how Cassia tora extracts affect insulin resistance and hyperglycemia. However, the effects of Cassia tora extracts on mitochondrial dysfunction associated with insulin secretion have not been well explained. In this study, well-known effective compounds extracted from Cassia tora using 70% ethanol were administered to a high-fat diet (HFD) fed mouse to examine the effects of Cassia tora ethanolic extracts (CSEE) on mitochondrial dysfunction in the pancreas. Furthermore, we examined how CSEE regulates the basal mechanism of insulin secretion through mitochondrial functions. Our experimental data suggest that pancreatic mitochondrial metabolism in HFD mice is enhanced to compensate for constrained glucose consumption. HFD-fed mice treated with CSEE showed improved pancreatic mitochondrial functions resulting in alleviation of insulin resistance at target tissue as well as basal hyperinsulinemia.
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