试剂
混合(物理)
扩散
肽
相(物质)
化学
组合化学
固相合成
肽合成
加速度
材料科学
化学工程
色谱法
有机化学
热力学
物理
工程类
生物化学
经典力学
量子力学
作者
Johnny N. Naoum,Israel Alshanski,Guy Mayer,Poriah Strauss,Mattan Hurevich
标识
DOI:10.1021/acs.oprd.1c00304
摘要
Accelerating solid-phase synthesis is crucial for accessing a large number of peptides in a short time. Since standard peptide synthesis is usually done under poor diffusion conditions with slow or no mixing of the solid support, acceleration of the process is achieved by applying a large excess of reagents. In this work, overhead stirring and heating were combined to provide accelerated solid-phase peptide synthesis without using an excess of reagent. A new setup that allows both heating and fast stirring was designed specifically for research laboratory-scale peptide synthesis. By increasing the diffusion of both reagents and beads in a narrow dimension reactor, solid-phase reactions were done in seconds and medium-size peptides were synthesized in minutes.
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