光遗传学
沟道视紫红质
神经科学
扁桃形结构
刺激
侵略
心理学
精神科
作者
Aiste Baleisyte,Ralf Schneggenburger,Olexiy Kochubey
出处
期刊:Cell Reports
[Elsevier]
日期:2022-05-01
卷期号:39 (8): 110850-110850
被引量:16
标识
DOI:10.1016/j.celrep.2022.110850
摘要
Summary
The medial amygdala (MeA) receives pheromone information about conspecifics and has crucial functions in social behaviors. A previous study showed that activation of GABA neurons in the postero-dorsal MeA (MeApd) with channelrhodopsin-2H134R (ChR2) stimulates inter-male aggression. When performing these experiments using the faster channelrhodopsinH134R,E123T (ChETA), we find the opposite behavioral outcome. A systematic comparison between the two channelrhodopsin variants reveals that optogenetic activation of MeApd GABA neurons with ChETA suppresses aggression, whereas activation under ChR2 increases aggression. Although the mechanism for this paradoxical difference is not understood, we observe that activation of MeApd GABA neurons with ChR2 causes larger plateau depolarizations, smaller action potentials, and larger local inhibition than with ChETA. Thus, the channelrhodopsin variant used for in vivo optogenetic experiments can radically influence the behavioral outcome. Future work should continue to study the role of specific sub-populations of MeApd GABA neurons in aggression control.
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