Sensitive Electrochemical Determination of Baicalein Based on D‐Ti3C2Tx MXene/Fullerene Composite Modified Glassy Carbon Electrode

Abstract In this work, an electrochemical sensor was developed based on the delaminated titanium carbide nanosheet (d‐Ti 3 C 2 T x ) and fullerene (C 60 ) composite modified glassy carbon electrode (GCE). The composite materials d‐Ti 3 C 2 T x /C 60 were characterized by scanning electron microscopy (SEM), X‐ray diffraction (XRD), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The prepared modified electrode (d‐Ti 3 C 2 T x /C 60 /GCE) exhibited commendable electrocatalytic activity for the oxidation of baicalein. Under the optimum detection conditions, the detection of baicalin showed a wide linear range of 0.015–4.0 μM with a detection limit of 0.005 μM. In addition, the d‐Ti 3 C 2 T x /C 60 /GCE showed good reproducibility, stability and anti‐interference. It was also successfully used for the determination of baicalin in the commercially available Shuanghuanglian oral liquid with satisfactory results.