原子力显微镜
人类免疫缺陷病毒(HIV)
机械生物学
机制(生物学)
显微镜
纳米技术
功能(生物学)
物理
生物
材料科学
病毒学
细胞生物学
光学
量子力学
作者
Itay Rousso,Akshay Deshpande
出处
期刊:Viruses
[MDPI AG]
日期:2022-03-21
卷期号:14 (3): 648-648
被引量:6
摘要
Obtaining an understanding of the mechanism underlying the interrelations between the structure and function of HIV-1 is of pivotal importance. In previous decades, this mechanism was addressed extensively in a variety of studies using conventional approaches. More recently, atomic force microscopy, which is a relatively new technique with unique capabilities, has been utilized to study HIV-1 biology. Atomic force microscopy can generate high-resolution images at the nanometer-scale and analyze the mechanical properties of individual HIV-1 virions, virus components (e.g., capsids), and infected live cells under near-physiological environments. This review describes the working principles and various imaging and analysis modes of atomic force microscopy, and elaborates on its distinctive contributions to HIV-1 research in areas such as mechanobiology and the physics of infection.
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