伏马菌素
伏马菌素B1
遗传毒性
表观遗传学
致癌物
真菌毒素
鞘脂
生物
药理学
毒理
毒性
生物化学
食品科学
医学
内科学
基因
作者
I.B. Molina-Pintor,Aurora Elizabeth Rojas-García,Irma Martha Medina-Díaz,Briscia Socorro Barrón-Vivanco,Yael Yvette Bernal-Hernández,L. Ortega-Cervantes,Ana M. González Ramos,José Francisco Herrera-Moreno,Cyndia Azucena González-Arias
摘要
Fumonisins (FBs), a widespread group of mycotoxins produced by Fusarium spp., are natural contaminants in cereals and foodstuffs. Fumonisin B 1 (FB 1 ) is the most toxic and prevalent mycotoxin of this group, and it has been reported that FB 1 accounts for 70-80% of FBs produced by the mycotoxigenic strains. The mode of action of FB 1 depends on the structural similarity with sphinganine/sphingosine N-acyltransferase. This fact causes an accumulation of sphingoid bases and blocks the sphingolipid biosynthesis or the function of sphingolipids. Diverse toxic effects and diseases such as hepatocarcinogenicity, hepatotoxicity, nephrotoxicity, and cytotoxicity have been reported, and diseases like leukoencephalomalacia in horses and pulmonary oedema in horses and swine have been described. In humans, FBs have been associated with oesophageal cancer, liver cancer, neural tube defects, and infantile growth delay. However, despite the International Agency for Research on Cancer designated FB 1 as a possibly carcinogenic to humans, its genotoxicity and epigenetic properties have not been clearly elucidated. This review aims to summarise the progress in research about the genotoxic and epigenetics effects of FB 1 .
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