金标准(测试)
考试(生物学)
计算机科学
诊断试验
统计
选择(遗传算法)
数学
医学
人工智能
生物
古生物学
急诊医学
作者
C Heuer,M.A. Stevenson
出处
期刊:Revue Scientifique Et Technique De L Office International Des Epizooties
[O.I.E (World Organisation for Animal Health)]
日期:2021-01-01
卷期号:40 (1)
被引量:1
标识
DOI:10.20506/rst.40.1.3223
摘要
Before tools became available to consider diagnostic test validation studies where a ‘gold-standard’ is not available, new diagnostic tests were compared to a reference standard assumed to be highly accurate if not perfect. This paper reviews such ‘traditional’ situations with examples and methods of study design and analysis. Three situations are described, two where a perfect reference is available for either positive or negative animals, and one where the reference is perfect for both. Thus, here the authors review circumstances to be considered when validating a diagnostic test with a credible reference standard. An appropriate study design requires an unbiased selection of animals from the population to which a new test will be applied. Examples for calculating sample size and data analysis are provided. Finally, the authors discuss situations where it may be appropriate to include influential variables (‘covariates’) in a diagnostic test validation study..
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