Synthesis, Characterization and Antimicrobial study of piperidine-2,6-diones derivatives

The piperidine ring is a structural feature of many alkaloids and drug [1] candidates and there were thousands of piperidine compounds mentioned in clinical and preclinical studies[2]. The piperidine ring system is one of the commonest structural sub units in natural compounds. Several substituted piperidines display important biological properties like antiviral activity. We have used a simple and highly efficient method for the synthesis of 1-(4- chlorophenyl) piperidine-2,6-diones. The reaction was optimized by using various solvents with some modifications in reaction conditions. The synthesized compounds are a precursor for dichlorodialdehydes 1, 4-DHP. Characterization of all synthesized piperidine-dione derivatives was done by analytical technique such as FTIR, 1HNMR. The resulting compounds possess symmetrical structures [3] and have high yields. All the compounds were screened for antimicrobial activities.