Effects of Flavonoids Extracted from the Diaphragma of Walnut (Juglans regia L.) on Spatial Memory of the Aged-model Mice

Flavonoids from the diaphragma of walnut has good antioxidant capacity.In this study, the D-galactose induced aging mice were gavaged by flavonoids extracted from walnuts diaphragm with three different doses (low, medium and high).Results showed that D-galactose can reduce the content of unsaturated fatty acids in the brain, however, compared with the model groups, the content of unsaturated fatty acids in the brain was significantly increased in the low-dose group, medium-dose group and high-dose group, especially the content of EPA and DHA, which can inhibit the aging of mice.The biopsy of brain tissue showed that the diaphragma of walnut have some protective effects on brain tissue.