The effect of Carica papaya seed extracts on urea, creatinine and uric acid levels in Wistar rats

This study investigated the effect of Carica papaya seeds on renal function parameters. Male Wistar rats aged 7± 1weeks, and weighing 70.0-105.0g, were used for the study and the animals were divided into four groups -A, B, C and D. Group A served as control, while B, C and D, served as test groups. The test groups were further subdivided into three -B1 – B3, C1 – C3 and D1 – D3 (n=4 each) and they received a combination of both ripe and unripe  Carica papaya seeds; ripe Carica papaya seeds only; and unripe Carica papaya seeds only, respectively. At the end of the experimental period of six (6) weeks, blood samples were obtained from the groups and analyzed for urea, creatinine and uric acid levels using standard methods. The statistical analysis of the data obtained was performed using the SPSS package (version 20) and results showed a dosage dependent and statistically significant increase in urea, creatinine and uric acid levels irrespective of the type; suggesting that Carica papaya ’s has capacity to induce alterations in renal function. Thus, there is an urgent need to regulate the inclusion of Carica papaya seeds in herbal preparations; particularly in those used for the management of kidney diseases. Keywords: Carica papaya , Urea. Creatinine, Uric acid, Renal function