喜树碱
PEG比率
生物相容性
聚乙二醇
体内分布
药物输送
化学
纳米颗粒
聚乙二醇化
药理学
药品
纳米技术
材料科学
体外
生物化学
有机化学
医学
财务
经济
作者
Kefeng Liu,Dan Zheng,Hantian Lei,Jing Liu,Jiandu Lei,Luying Wang,Xiaochun Ma
出处
期刊:ACS Biomaterials Science & Engineering
[American Chemical Society]
日期:2018-04-04
被引量:20
标识
DOI:10.1021/acsbiomaterials.8b00260
摘要
The clinical applications of natural anticancer drugs are being restricted by poor water solubility, fast clearance in the circulation, lack of targeting to tumor cells, and poor tissue penetration. To address these problems, in this study, we developed a novel lignin-based targeted polymeric nanoparticles (NPs) platform, folic acid-polyethylene glycol-alkaline lignin conjugates (FA-PEG-AL), via self-assembly for delivery of anticancer drug (hydroxyl camptothecin, HCPT). These lignin-based nanoparticles had moderate particle size (∼150 nm) with a narrow size distribution (PDI < 0.1), exhibited excellent biocompatibility, high drug loading efficiency (∼24.2 wt % of HCPT), prolonged blood circulation time (∼7-fold of free HCPT), and enhanced cellular uptake (∼5-fold of free HCPT). Besides, the drug biodistribution study confirmed preferred accumulation of FA-PEG-AL/HCPT NPs in tumor tissue. Subsequent tumor xenograft test revealed superior tumor suppression efficacy and reduced side effects of FA-PEG-AL/HCPT NPs compared with free HCPT. Therefore, the prepared lignin-based FA-PEG-AL/HCPT NPs would be a promising candidate for anticancer drugs delivery.
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