化学
小学(天文学)
烷基化
生物催化
酒
醇脱氢酶
米曲霉
有机化学
伯醇
酒精氧化
酶
催化作用
组合化学
离子液体
天文
物理
作者
Sarah L. Montgomery,Juan Mangas‐Sánchez,Matthew P. Thompson,Godwin A. Aleku,Beatriz Domı́nguez,Nicholas J. Turner
标识
DOI:10.1002/anie.201705848
摘要
The reductive aminase from Aspergillus oryzae (AspRedAm) was combined with a single alcohol dehydrogenase (either metagenomic ADH-150, an ADH from Sphingobium yanoikuyae (SyADH), or a variant of the ADH from Thermoanaerobacter ethanolicus (TeSADH W110A)) in a redox-neutral cascade for the biocatalytic alkylation of amines using primary and secondary alcohols. Aliphatic and aromatic secondary amines were obtained in up to 99 % conversion, as well as chiral amines directly from the racemic alcohol precursors in up to >97 % ee, releasing water as the only byproduct.
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