J2410103 Development of Machine perfusion system for Kidney and Liver Transplantation

Novel machine perfusion systems for liver and kidney preservation are introduced and evaluated. Utilization of grafts from donors after cardiac death would greatly contribute to the expansion of the donor organ pool. However, there are many difficulties using them with a conventional static cold organ storage. It is important to develop new strategy with novel engineering system. This system is able to control perfusion flow condition and temperature from hypothermic perfusion condition to the subnormothermic perfusion condition. This system is not only effective for organ preservation with removing waste products and supplying oxygen and nutrients for metabolism but also available for the evaluation of graft viability and recovery functions during machine perfusion. This novel method has been proposed for preservation study of porcine liver grafts using a temperature-controlled perfusion model.