化学
薗头偶联反应
炔基化
催化作用
激进的
组合化学
偶联反应
甲烷氧化偶联
烷基
金属
光化学
钯
有机化学
作者
Shan Tang,Yichang Liu,Xinlong Gao,Pan Wang,Pengfei Huang,Aiwen Lei
摘要
A new way for C(sp3)–C(sp) cross-coupling with terminal alkynes has been developed by using a multi-metal-catalyzed reaction strategy. Alkyl radicals generated from different approaches are able to couple with terminal alkynes by judicious selection of the catalyst combination. This reaction protocol offers an efficient alternative approach for the synthesis of substituted alkynes from terminal alkynes besides traditional Sonogashira coupling. Mechanistic studies have also been carried out to clarify the role of each metal catalyst in the radical alkynylation processes. The reactions were found to go through radical reaction pathways. Synergistic cooperation of the metal catalysts is the key for controlling the reaction selectivity of alkyl radicals toward C(sp3)–C(sp) bond formation.
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