The Blood Retinal Interface: Similarities and Contrasts with the Blood‐Brain Interface

This chapter contains sections titled: Introduction The Inner and Outer BRB The Choroidal Vasculature Characteristics of Intraretinal Blood Vessels Ensheathment and Induction of the Inner BRB by Astrocytes and Müller Glia BRB Properties of Newly Formed Vessels Pericytes and the BRB Membrane Proteins of Tight Junctions Localization of Occludin and Claudin-1 to Tight Junctions of Retinal Vascular Endothelial Cells Expression of Occludin by RPE Cells and Lack of Occludin Expression by Choroidal Vessels Inherent Weakness of the BRB and Existence of Resident MHC Class II+ Cells Predisposes the Optic Nerve Head to Inflammatory Attack Compromised BBB Where CNS Meets Peripheral Vascular Bed Clinical and Experimental Determination of the Blood-Retinal Barrier Conclusions References