氧化应激
共识序列
抗氧化剂
鉴定(生物学)
序列(生物学)
DNA
DNA测序
活性氧
氧化磷酸化
计算生物学
化学
生物
遗传学
生物化学
基序列
植物
作者
Thomas H. Rushmore,Marcia R. Morton,Cecil B. Pickett
标识
DOI:10.1016/s0021-9258(18)99004-6
摘要
We have characterized further the antioxidant responsive element (ARE) identified in the 5'-flanking region of the rat glutathione S-transferase Ya subunit gene and the NAD(P)H:quinone reductase gene by mutational and deletion analyses. Our data suggest that the sequence, 5'-puGTGACNNNGC-3' 3'-pyCACTGNNNCG-5' where N is any nucleotide, represents the core sequence of the ARE required for transcriptional activation by phenolic antioxidants and metabolizable planar aromatic compounds (e.g. beta-naphthoflavone and 3-methylcholanthrene). We also have found that the ARE is responsive to hydrogen peroxide and phenolic antioxidants that undergo redox cycling. These latter data suggest that the ARE is responsive to reactive oxygen species and thus may represent part of a signal transduction pathway that allow eukaryotic cells to sense and respond to oxidative stress.
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