Chemical Synthesis of Mono- and Bis-Labeled Pre-MicroRNAs

A chemical method for the post-synthetic labeling of pre-miRNAs on solid support using easily accessible reagents was developed. The procedure was employed to generate a library of 31 pre-microRNAs carrying labels commonly used in chemical biology, including Cy3, trioxalen, biotin, and BHQ-1. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.