纤维蛋白
小泡
凝结
体内
体外
恶性肿瘤
化学
腹水
细胞生物学
生物
病理
免疫学
癌症研究
生物化学
膜
医学
内科学
生物技术
作者
Dvorak Hf,Steven C. Quay,NS Orenstein,Dvoràk Am,Peter F. Hahn,Bitzer Am,Carvalho Ac
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1981-05-22
卷期号:212 (4497): 923-924
被引量:276
标识
DOI:10.1126/science.7195067
摘要
Three syngeneic carcinomas from two species shed plasma membrane vesicles when cultured in vitro or grown in the ascites tumor form in vivo. Shed vesicles carry procoagulant activity that can account for the activation of the clotting system and the fibrin deposition associated with these and many other types of malignancy in animals and man.
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