A systematic concept in bioprocess analysis and design

Abstract A systematic concept in bioprocess analysis and design is presented according to an integrating strategy as basis for a biotechnological methodology. A comparison illustrates analogies and significant differences between chemical and biological processes. The study of the interactions between environments and organisms includes influences of physical transport phenomena and also enzyme and metabolic regulations. In both cases the macroscopic principle with a formalkinetic approach is recommended for quantification purposes. The determination of the characteristic‐time‐regime with characteristic rate constants makesit possible to simplify mathematical modeling using the concepts of the rate‐determining‐step and quasistationarity. Finally, guidelines are summarized for the use of unstructured and structured kinetic models.