丁酰胆碱酯酶
乙酰胆碱酯酶
化学
胆碱酯酶
IC50型
药理学
酶
酶抑制
阿切
组合化学
立体化学
生物化学
体外
医学
作者
Jamshed Iqbal,Maria Stuckart,Masooma Ibrahim,Syed M. Usman Ali,Aftab Ahmed Khan,Ulrich Kortz
标识
DOI:10.1007/s00044-012-0125-8
摘要
Polyoxometalates (POMs) show significant importance in medicine due to their enzyme inhibition, antiviral and anticancer properties. In this study, some polyoxotungstates were identified as potent inhibitors of acetyl and butyrylcholinesterases. Compounds [H2W12O42]10− and [TeW6O24]6− have the most potent acetylcholinesterase activity, exhibiting IC50 values of 0.29 ± 0.01 and 0.31 ± 0.01 μM, respectively. Whereas, compound [(O3PCH2PO3)4W12O36]16− was a potent and selective inhibitor of butyrylcholinesterase with IC50 value of 0.18 ± 0.05 μM. In general, POMs were found to be effective cholinesterase inhibitors in terms of efficiency as well as selectivity and represent non-classical cholinesterase inhibitors.
科研通智能强力驱动
Strongly Powered by AbleSci AI