Synthesis and in vitro study of some fused 1,2,4-triazole derivatives as antimycobacterial agents

Because of the highly therapeutic nature of 1,2,4-triazoles, a new class of fused pyrazolo [3′,4′:4,5] thiazolo [3,2-b] [1,2,4]-triazole, isoxazolo [3′,4′:4,5] thiazolo [3,2-b] [1,2,4]-triazole moieties were prepared from the novel conventional methods via the reaction of 4-methyl benzoyl thiosemicarbazide with the appropriate chemical reagents. These compounds were screened for their antimicrobial activity against various bacterial and fungal strains. With the reference of antimicrobial activity data the synthesized compounds were further screened for their antimycobacterial activity against Mycobacterium tuberculosis H37Rv by the conventional methods. Among the synthesized compounds 4b, 4d, 4h, 5d and 5h have shown more activity compared to the standard drugs.