医学
严重肢体缺血
骨髓
灌注
外科
间充质干细胞
糖尿病足
缺血
截肢
生理盐水
糖尿病
泌尿科
内科学
干细胞
外周血单个核细胞
病理
血管疾病
内分泌学
动脉疾病
化学
体外
生物
生物化学
遗传学
作者
Debin Lu,Bing Chen,Ziwen Liang,Wuquan Deng,Yao‐Guang Jiang,Shufa Li,Jing Xu,Qinan Wu,Zhonghui Zhang,Bing Xie,Sihao Chen
标识
DOI:10.1016/j.diabres.2010.12.010
摘要
To identify better cells for the treatment of diabetic critical limb ischemia (CLI) and foot ulcer in a pilot trial.Under ordinary treatment, the limbs of 41 type 2 diabetic patients with bilateral CLI and foot ulcer were injected intramuscularly with bone marrow mesenchymal stem cells (BMMSCs), bone marrow-derived mononuclear cells (BMMNCs), or normal saline (NS).The ulcer healing rate of the BMMSC group was significantly higher than that of BMMNCs at 6 weeks after injection (P=0.022), and reached 100% 4 weeks earlier than BMMNC group. After 24 weeks of follow-up, the improvements in limb perfusion induced by the BMMSCs transplantation were more significant than those by BMMNCs in terms of painless walking time (P=0.040), ankle-brachial index (ABI) (P=0.017), transcutaneous oxygen pressure (TcO(2)) (P=0.001), and magnetic resonance angiography (MRA) analysis (P=0.018). There was no significant difference between the groups in terms of pain relief and amputation and there was no serious adverse events related to both cell injections.BMMSCs therapy may be better tolerated and more effective than BMMNCs for increasing lower limb perfusion and promoting foot ulcer healing in diabetic patients with CLI.
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