流行病学
口蹄疫
柯萨奇病毒
肠道病毒71
肠道病毒
疾病
爆发
入射(几何)
公共卫生
医学
病毒学
基因型
手足口病
环境卫生
生物
病毒
内科学
病理
光学
物理
基因
生物化学
作者
Lianlian Bian,Fan Gao,Qunying Mao,Shiqi Sun,Xing Wu,Siyuan Liu,Xiaoming Yang,Zhenglun Liang
标识
DOI:10.1080/14787210.2019.1585242
摘要
Hand, foot, and mouth disease (HFMD) is a common viral childhood illness, that has been a severe public health concern worldwide, particularly in the Asia-Pacific region. According to epidemiological data of HFMD during the past decade, the most prevalent causal viruses were enterovirus (EV)-A71, coxsackievirus (CV)-A16, CV-A6, and CV-A10. The public health burden of CV-A10-related diseases has been underestimated as their incidence was lower than that of EV-A71 and CV-A16 in most HFMD outbreaks. However, cases of CV-A10 infection are more severe, and its genome is more variable, which has alerted the research community worldwide. Areas covered: In this paper, studies on the epidemiology, laboratory diagnosis, clinical manifestations, molecular epidemiology, seroepidemiology, animal models of CV-A10, and vaccines and antiviral strategies against this genotype are reviewed. In addition, the genetic evolution of circulating strains was analyzed. Expert opinion: Multivalent vaccines against EV-A71, CV-A16, CV-A6, and CV-A10 should be a next-step HFMD vaccine strategy.
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