医学
压力反射
肾素-血管紧张素系统
背景(考古学)
血管紧张素II
疾病
受体
血压
中枢神经系统
神经科学
血管紧张素受体
药理学
生物信息学
内科学
生物
心率
古生物学
作者
Vasiliki Katsi,Spyridon Maragkoudakis,Maria E. Marketou,Costas Tsioufis,Fragkiskos Parthenakis,Dimitrios Tousoulis
出处
期刊:Current Vascular Pharmacology
[Bentham Science]
日期:2019-06-11
卷期号:17 (4): 319-325
被引量:6
标识
DOI:10.2174/1570161117666181105154843
摘要
: In recent years, the Angiotensin-(1-7)/Mas receptor [Ang-(1-7)/Mas] sub-branch of the Renin-Angiotensin System (RAS) in the brain, and Angiotensin Type 2 Receptors (AT2R), have attracted scientific interest, as there is evidence that they constitute an essential pathway in cardiovascular regulation, in health and in disease. By acting centrally, the Ang-(1-7)/Mas axis - that has been termed ‘the axis of good’- can exert blood pressure-lowering effects, while also favourably altering baroreflex sensitivity and noradrenergic neurotransmission. Thus, research has focused on the possible neuro- and cardioprotective effects of this pathway in the setting of cardiovascular disease, ultimately aiming to evaluate the potential for development of novel therapeutic strategies based on its modulation. : We summarize the available evidence from experimental studies in this context, aiming to assess current limits of scientific knowledge relevant to this newly-described ‘player’ in haemodynamic regulation, that may become a potential therapeutic target.
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