N‐Acyl‐Glutarimides: Privileged Scaffolds in Amide N–C Bond Cross‐Coupling

In this Microreview, we describe the recent exciting developments in the burgeoning area of amide N–C cross‐coupling enabled by amide bond twist of N ‐acyl‐glutarimides. Since the initial reports in 2015, these amides have been demonstrated to be by far the most reactive amide derivatives in the biologically‐relevant manifold of N–C activation/cross‐coupling, thus stimulating the development of more than 10 previously unknown catalytic modes of reactivity of the amide bond. The capacity of N ‐acyl‐glutarimides as privileged scaffolds to expedite acyl and decarbonylative cross‐couplings by amide N–C cleavage is discussed.