毛囊素
肾癌
癌症
疾病
生物
医学
生物信息学
癌症研究
肾
肾脏疾病
内科学
遗传学
基因
作者
W. Marston Linehan,Laura S. Schmidt,Daniel R. Crooks,Darmood Wei,Ramaprasad Srinivasan,Martin Lang,Christopher J. Ricketts
出处
期刊:Cancer Discovery
[American Association for Cancer Research]
日期:2019-08-01
卷期号:9 (8): 1006-1021
被引量:159
标识
DOI:10.1158/2159-8290.cd-18-1354
摘要
Abstract Kidney cancer is not a single disease but represents several distinct types of cancer that have defining histologies and genetic alterations and that follow different clinical courses and have different responses to therapy. Mutation of genes associated with kidney cancer, such as VHL, FLCN, TFE3, FH, or SDHB, dysregulates the tumor's responses to changes in oxygen, iron, nutrient, or energy levels. The identification of these varying genetic bases of kidney cancer has increased our understanding of the biology of this cancer, allowing the development of targeted therapies and the appreciation that it is a cancer driven by metabolic alterations. Significance: Kidney cancer is a complex disease composed of different types of cancer that present with different histologies, clinical courses, genetic changes, and responses to therapy. This review describes the known genetic changes within kidney cancer, how they alter tumor metabolism, and how these metabolic changes can be therapeutically targeted.
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