穿心莲内酯
肺炎克雷伯菌
穿心莲
亚胺培南
微生物学
医学
抗生素
肺炎克雷伯菌
药理学
化学
生物
细菌
抗生素耐药性
铜绿假单胞菌
生物化学
大肠杆菌
病理
替代医学
基因
遗传学
作者
Guorong Zhang,Chunhong Jiang,Ning Xie,Yuzhu Xu,Li Liu,Nan Liu
标识
DOI:10.1016/j.biopha.2019.109065
摘要
Klebsiella pneumoniae is a primary cause of community-acquired and nosocomial respiratory infections, and K. pneumoniae resistance to the current treatment approach with carbapenem is worsening. Andrographolide is a natural diterpenoid from Andrographis paniculata that was shown to exert anti-inflammatory activity. We herein show that pretreatment with a water-soluble andrographolide sulfonate significantly attenuate lung injury and infiltration of inflammatory cells. Interestingly, mice receiving combined treatment with andrographolide sulfonate displayed perfect survival rate than the mice treatment with imipenem alone, and monocyte chemotactic protein 5 (MCP-5) level was decreased further. These findings suggest that andrographolide sulfonate could as a potential synergist for antibiotic treatment of bacteria-induced inflammation.
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