Methods: Forty-two patients with paroxysmal AF undergoing PVI were studied. Patients undergoing cryoballoon ablation (Cryo: n=15) were compared with patients undergoing RF ablation (RF: n=27). We evaluated biomarkers and LA volume before and 1 month after,and 6-month after PVI. LA diameter and volume were measured by two-dimensional and three-dimensional speckle tracking echocardiography, including ventricular systolic LA strain (LA-Ss) and atrial systolic LA strain (LA-Sa). Results: In Laboratory data, creatine kinase (CK) level after ablation was significantly higher in Cryo group compared to RF group (275.7±125.3 vs. 158.4±53.5, p<0.01). Preoperative and 6-month after ablation HANP level of Cryo group was significantly higher than RF group. In Echocardiographic data, LA volume was no significantly change in both groups, but LA-EF of 6-month after cryoballoon ablation was significantly improved in comparison with RF ablation. LA-Sa of 1 month after RF ablation was significantly lower than before. LA-Sa after cryoballoon ablation was improved 6-month after.