Synthesis Of Novel System Spiro-Heterocyclic By Diels-Alder Reaction Catalysed With Ticl4 For [4+2] Cycloaddion

We have developed a novel system of organic spiro-heterocyclic compounds: like diazaspiro- [5.5] undec-8-ene and oxaspiro [bicyclo [2,2,1 ] heptane-2,1-cyclohexane] dione system with the reaction of Diels-Alder catalyzed with TiCl4 in high regio and stereo-selective way and excellent yield. Initially, we developed different dienophiles and confirmed their structures by spectroscopic methods, 1H NMR, 13C-NMR.then we studied the mechanistic and stereo-chemical action of the various dienophiles concerning the dienes. Finally, the structure of the various newly synthesized products was established by the spectroscopic methods: 1H-NMR, 13C-NMR, the stereochemical aspects of the Diels-Alder reaction, and cycloaddition [4 + 2] were established, and the reaction conditions were mentioned.16, 17