Au-Nanoparticles Based Sensors for Voltammetric Determination of Glutathione

Background: Glutathione (GSH) is a water-soluble tripeptide which is contained in biological fluids (blood plasma, cell fluid) and plays an important role in redox processes in the organisms of humans and animals. The lack of GSH leads to oxidative stress in living cells and causes dangerous diseases. In this regard, the development of rapid and simple analytical methods to determine GSH in biological fluids is an important task. The purpose of the present paper was to explore the possibility of electrochemical determination of GSH using AuNPs-modified graphite electrodes to develop a sensitive voltammetric method. Keywords: Cyclic voltammetry, electrocatalysis, glutathione, gold nanoparticles, biological fluids, redox processes.