Posttranslational Modifications of Autophagy-related Proteins

Autophagy is an evolutionarily conserved cellular catabolic pathway in response to metabolic stresses.Autophagy is activated with the formation of double-membrane structures named autophagosome,which can ferry cytoplasmic impaired organelles and proteins to the lysosome for degradation.Autophagy is regarded as a quality control mechanism that contributes to the maintainance of cell homeostasis.By far,the core proteins involved in the classical autophagy pathway have been identified.The activity and function of these proteins in autophagy flux following stress signal inputs is being investigated.We reviewed recent studies about the regulation of autophagy-related proteins with posttranslational modifications under conditions of metabolic stresses,in order to help the further understanding of autophagy.