Distributions and clinical significances of HPV genotypes in different cervical lesions in Xinjiang Uygur Autonomous Region from 2009 to 2013

Objective: To explore the distributions and clinical significances of human papillomavirus( HPV) genotypes in different cervical lesions in Xinjiang Uygur Autonomous Region from January 2009 to December 2013. Methods: A total of 11 256 women receiving cervical cancer screening voluntarily from January 2009 to December 2013 were selected as study objects,liquid-based cytology test( LCT) was performed; flow-through hybridization method was used to detect HPV DNA in cervical cells,and genotyping was conducted among high risk HPV( HR-HPV); cervical colposcopic biopsy was carried out in patients with HR-HPV. Results: After LCT,6 896 women were found with normal cervix; after colposcopic biopsy,2 125 women were diagnosed as low-grade squamous intraepithelial lesion( LSIL),1 779 women were diagnosed as high-grade squamous intraepithelial lesion( HSIL),456 women were diagnosed as invasive cervical cancer( ICC),the total positive rates of HPV in the four groups were 1. 48%,21. 32%,53. 74% and 88. 16%,respectively. The top five genotypes among HR-HPV were HPV 51( 30. 82%),HPV 16( 23. 56%),HPV 35( 18. 00%),HPV 18( 10. 65%) and HPV 52( 7.26%),respectively; the proportions of HPV 51,HPV 16,HPV 35,HPV 18 and HPV 52 in normal cervix group,LSIL group,HSIL group and ICC group were 20. 00%,10. 00%,10. 00%,5. 00%,10. 00%; 46. 43%,21. 43%,16. 07%,2. 68%,0. 89%; 25. 38%,20. 93%,19. 38%,13. 38%,10. 63%; 35. 55%,29. 48%,16. 76%,8. 96%,3. 47%,respectively. Conclusion: HPV infection rate shows an increasing trend among the women in Xinjiang Uygur Autonomous Region,HPV detection rate increases significantly with aggravation of cervical lesions,HPV-16 /18 are the most common HR-HPV genotypes. HR-HPV DNA detection is helpful to early diagnosis of cervical cancer,which has important clinical significance.